However, the same studies reported between 10 and 20% of infections to have double mutant alleles of dhfr (combinations of variants at codons 58, 61 and 117) [41,42], in contrast to results here that showed an absence of resistance-associated alleles at these codons (except for a single variant at codon 117 in infection sample NKT136 that had an overall genotype similar to Asian parasites). The gene discussed is DHFR; the disease is infection.