GYPB and malaria: Recently, a large structural variant in the chromosome 4 GYP region that gives rise to the Dantu glycophorin (DUP4) has been associated with about a 40% reduction in risk for severe malaria.9,27 Interestingly, this Dantu variant was found predominantly in East African populations, but there are many other common structural variants across all the West and East African populations that have been studied.9 The most common variants identified were deletions of the whole GYPB gene and the surrounding region known as GYPB DEL1 and GYPB DEL2 (Figure 1).