Interestingly, seven genes of the eight gene estimator, TP53, SF3B1, ATM, NOTCH1, XPO1, BIRC3, and MYD88 are part of the nine genes used by Guièze et al41 to show that a multihit mutational profile is associated with a much shorter progression‐free survival in relapsed/refractory CLL. This evidence concerns the gene BIRC3 and B-cell chronic lymphocytic leukemia.