Description of the mutational landscape either by whole exome or whole genome sequencing identified new mutations in CLL such as those of SF3B1, NOTCH1, BIRC3 that are associated with a poor prognosis as well as CLL driving mutations such as those of ATM or MYD88.11, 12, 13, 14. This evidence concerns the gene NOTCH1 and B-cell chronic lymphocytic leukemia.