Because Akt hyperactivation in pancreatic cancer cells results in subsequent inhibition of Raf and mitogen‐activated protein kinase kinase (MEK)/Erk1/2 pathway,54 and that MEK1/2 inhibition results in PI3K/Akt pathway activation in CRC cells,56 these two pathways take over from each other. The gene discussed is MAP2K1; the disease is familial pancreatic carcinoma.