In fact, the Akt activation observed in 5‐FU‐resistant CRC cells from low tumour grade cells (WiDr) could be consistent with the no significant Erk modification; and the Akt inhibition observed in 5‐FU‐resistant CRC cells from high tumour grade cells (SW620) could be consistent with increased Erk activation. This evidence concerns the gene AKT1 and colorectal carcinoma.