MAPK1 and nervous system disorder: The extracellular regulated kinase (ERK) pathway also has been implicated in neurological disorders and neural processes like extinction (Radulovic and Tronson, 2010; Vithayathil et al., 2018; Albert-Gascó et al., 2020) and is a parallel signaling pathway to AKT that can have crosstalk (York et al., 2000; Perkinton et al., 2002; Sutton and Chandler, 2002; Jones et al., 2003).