AKT1 and schizophrenia: Schizophrenia, for example, has been associated with SNPs in AKT1 (Ikeda et al., 2004; Tan et al., 2008; Blasi et al., 2011; Karege et al., 2012) and AKT3 (Psychosis Endophenotypes International Consortium et al., 2014), reduced AKT1 levels in patient brains (Emamian et al., 2004), and pathogenic AKT signaling (Liu et al., 2013).