The functional enrichment analysis and GSEA showed that dysregulation of MAG, HOXB3, MYRF and PLP1, as well as their corresponding miRNAs and lncRNAs in the ceRNA network, contributes to the pathogenesis of PD via sphingolipid and glutathione metabolism signalling pathway, and these RNAs of interest were potential diagnostic and therapeutic targets of PD. Here, HOXB3 is linked to Parkinson disease.