Thus, it is speculated that dysregulation of HOXB3, ERBB3, ONECUT2, SH3TC2, PLP1, MAG, TNFSF14 and MYRF induces disorder in cranial nerve development, peripheral nervous system development, axon ensheathment in the central nervous system and cellular response to mechanical stimulus, which contributes to the pathogenesis of PD. This evidence concerns the gene HOXB3 and Parkinson disease.