Transactive response DNA binding protein 43 (TDP-43) inclusions are hallmarks of certain Frontotemporal Dementias (FTLD) and Amyotrophic Lateral Sclerosis (ALS; [41]) but have also now been demonstrated in DLB + AD, PD with or without dementia, and in around one third of mixed-dementia [37]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.