The C-terminus of ataxin-2 can associate with RBFOX1 (also known as A2BP1 or ataxin-2 binding protein 1), a protein containing a ribonucleoprotein motif that is highly conserved among RNA-binding proteins and which was demonstrated to be important for alternative splicing, neural excitability and autism [32–34]. Here, RBFOX1 is linked to autism.