Similarly, in the present study, we observed an increase in many immune-related DEGs, such as IL6, IL1A, IL2RB, CCL2, CCL5, granulocyte chemotactic protein 2 (CXCL5), CXCL8, CXCL2, CX3C, chemokine ligand 1 (CX3CL1), and CCL20. We suggest these genes may serve as a sign for the discovery of bovines with subclinical endometritis and for supervising new therapy approaches and may assist in the development of more targeted and effective vaccines and drugs for the prevention and treatment of bovine endometritis. The gene discussed is IL1A; the disease is endometritis.