Fatty acid oxidation (Acadm, Etfdh, Acadl, Acadvl, Eci1, Hadh, Phyh, Acaa2, Hadha, Hadhb, Cd36), glucose metabolism (Dld, Pdha1, Pgam1, Pgam2, Acss1, Ldhb, Fh1, Slc2a4, Aldh6a1), TCA cycle (Aco2, Dld, Fh1, Ogdh, Sucla2, Sdha, Idh3b, Idh2) were up-regulated by hispidulin in cardiac hypertrophy. The gene discussed is ACSS1; the disease is cardiac hypertrophy.