Fatty acid oxidation (Acadm, Etfdh, Acadl, Acadvl, Eci1, Hadh, Phyh, Acaa2, Hadha, Hadhb, Cd36), glucose metabolism (Dld, Pdha1, Pgam1, Pgam2, Acss1, Ldhb, Fh1, Slc2a4, Aldh6a1), TCA cycle (Aco2, Dld, Fh1, Ogdh, Sucla2, Sdha, Idh3b, Idh2) were up-regulated by hispidulin in cardiac hypertrophy. The gene discussed is ACO2; the disease is cardiac hypertrophy.