Fatty acid oxidation (Acadm, Etfdh, Acadl, Acadvl, Eci1, Hadh, Phyh, Acaa2, Hadha, Hadhb, Cd36), glucose metabolism (Dld, Pdha1, Pgam1, Pgam2, Acss1, Ldhb, Fh1, Slc2a4, Aldh6a1), TCA cycle (Aco2, Dld, Fh1, Ogdh, Sucla2, Sdha, Idh3b, Idh2) were up-regulated by hispidulin in cardiac hypertrophy. The gene discussed is PHYH; the disease is cardiac hypertrophy.