Indeed, in settings of Ang II infusions at high rates (3,000 ng/kg/min), cardiac hypertrophy was found to have been reduced in TRIF deficient mice but aggravated in MyD88 knockout mice compared to wild type mice by measuring the ratio of heart weight to body weight, with a similar trend also observed in systolic blood pressure (97, 98). This evidence concerns the gene MYD88 and cardiac hypertrophy.