TLR4 and obesity due to melanocortin 4 receptor deficiency: In contrast, activation of the TLR4/MyD88 signaling pathway enhances CaMK II activity, thereby facilitating LV remodeling in the setting of chronic pressure overload or obesity to some extent (34, 38), illustrated that TLR4/MyD88/CaMK II pathway mediated inflammation involved hypertrophic remodeling.