Furthermore, the sustained neuro-hormonal activation leads to the generation of catecholamines and angiotensin II (Ang II) by the sympathetic-adrenomedullary system and the renin-angiotensin system (RAS), respectively, which contribute to ominous progression to hypertension and subsequent cardiac hypertrophy (19, 20). The gene discussed is AGT; the disease is cardiac hypertrophy.