As illustrated in Figures 3A–G, expression of seven CXCR members was closely associated with cancer stages of ccRCC patients, and patients with late stages (stage 3–4) tended to have higher mRNA expression of CXCR3/5/6 (Figures 3C,E,F). This evidence concerns the gene CXCR3 and nonpapillary renal cell carcinoma.