According to the results of PPI network, CXCRs mostly interact with CXCL1, CXCL6, CXCL8, CCR5, CCR3, CCL5, and APLN, and those hub genes in the PPI network could play important roles in the development and progression of ccRCC. This evidence concerns the gene CXCL1 and nonpapillary renal cell carcinoma.