Furthermore, it is reported that the CXCR5–CXCL13 axis could promote the progression of ccRCC (Zheng et al., 2018), and overexpression of CXCR5 facilitated tumor cell proliferation through JNK pathway in prostate cancer (El Haibi et al., 2010). Here, CXCL13 is linked to Familial prostate cancer.