According to the results of PPI network, CXCRs mostly interact with CXCL1, CXCL6, CXCL8, CCR5, CCR3, CCL5, and APLN, and those hub genes in the PPI network could play important roles in the development and progression of ccRCC. Here, CCL5 is linked to nonpapillary renal cell carcinoma.