SPP1 and laryngotracheoesophageal cleft: SPP1 is an integrin-binding glyco-phosphoprotein, which shows over-expression in a variety of tumors, such as liver cancer, LC, prostate cancer (PCa), BC, and CRC (Rangaswami et al., 2006; Blasberg et al., 2010; Kahles et al., 2014).