Expressions of MMP12 and SULF1 were associated with tumor progression or metastasis in COAD, HNSC, LUAD, and LUSC (Lai et al., 2004; Qu et al., 2011; Kim et al., 2013; Klupp et al., 2016; Xie et al., 2018; Wei et al., 2020). This evidence concerns the gene MMP12 and neoplasm.