In tumor tissue, SPP1 showed positive correlation with CD44 in LUAD (R = 0.22, P = 1.3e-06), COAD (R = 0.2, P = 0.00079), LUSC (R = 0.26, P = 4.7e-09), and HNSC (R = 0.1, P = 0.019), and was also associated with ITGB1 in COAD (R = 0.52, P = 3.3e-20), HNSC (R = 0.16, P = 0.00028), LUSC (R = 0.11, P = 0.017), and LUAD (R = 0.23, P = 1.8e-07). This evidence concerns the gene CD44 and neoplasm.