Combined with the analysis results of Oncomine database and TIMER database, this study discovered the high expression of SPP1 in the bladder cancer, brain cancer, cervical cancer, CRC, ESCA, GC, HNC, liver cancer, lymphoma, melanoma, pancreatic cancer and PCa, as so as KIRP, READ, STAD, THCA, UCEC, CHOL, COAD, LUAD, and LUSC compared to the normal tissues. Here, SPP1 is linked to melanoma.