Contrastingly, high SPP1 expression showed better prognosis in READ (OS HR = 0.39, 95% CI = 0.18-0.85, Cox P = 0.015), LIHC (OS HR = 0.63, 95% CI = 0.43-0.91, Cox P = 0.013), and pancreatic ductal adenocarcinoma (PAAD) (OS HR = 0.57, 95% CI = 0.38-0.88, Cox P = 0.011; RFS HR = 0.38, 95% CI = 0.13-1, Cox P = 0.043) (Figures 2C,F,I,J). The gene discussed is SPP1; the disease is pancreatic ductal adenocarcinoma.