SPP1 is an integrin-binding glyco-phosphoprotein, which shows over-expression in a variety of tumors, such as liver cancer, LC, prostate cancer (PCa), BC, and CRC (Rangaswami et al., 2006; Blasberg et al., 2010; Kahles et al., 2014). The gene discussed is SPP1; the disease is Familial prostate cancer.