The expression level of IGFL1 in the samples with high expression of IGFLR1 and low expression of IGFLR1 was compared and the influence of the expression level of IGFL1 in the samples with high expression of IGFLR1 on the prognosis of ccRCC patients was analyzed by “survival” R package. The gene discussed is IGFLR1; the disease is nonpapillary renal cell carcinoma.