Further, CSCs can modulate angiogenesis by producing proangiogenic factors such as VEGFA (Chand et al., 2016) to induce unregulated tumor angiogenesis and metastasis (Carmeliet and Jain, 2011; Treps et al., 2017; Sun et al., 2020; Figure 3 and Table 1). The gene discussed is VEGFA; the disease is neoplasm.