The anti-cancer drugs ABT263 and ABT737 can alleviate the senescence of lung fibroblasts by blocking the up-regulation of Bcl-2 family anti-apoptotic proteins, including Bcl-2, Bcl-XL, and Bcl-W (Chang et al., 2016; Yosef et al., 2016; Zhu et al., 2016). This evidence concerns the gene BCL2 and cancer.