The low activity of PTEN leads to the inactivation of the transcription activator FoxO3a through the PTEN/Akt-dependent pathway, down-regulates the expression of Cav-1 and Fas gene, and thus gives IPF fibroblasts an obvious anti-apoptotic phenotype (Nho et al., 2013). The gene discussed is FOXO3; the disease is idiopathic pulmonary fibrosis.