What is more, mTOR inhibitor Rapamycin, antioxidant N-acetylcysteine (NAC), and mitochondrial-targeted superoxide dismutase mito-TEMPO act on the ROS production and DDR response in mitochondria to suppress IPF fibroblast senescence (Schuliga et al., 2018). The gene discussed is MTOR; the disease is idiopathic pulmonary fibrosis.