RPS27 and pulmonary hypertension, primary, 1: We observed a significant reduction in the transcript levels of genes encoding a number of ribosomal proteins in the 60S (RPL30, RPL10A, RPL38, RPL22, RPL26, RPL18A, RPL12, RPL31) and 40S (RPS12, RPS15A, RPS10, RPS14, RPS6, RPS27) ribosome subunits in response to mTORC1 inhibition in PHT cells, which is consistent with previous reports demonstrating that mTORC1 controls the synthesis of ribosomal proteins in other cell types (Iadevaia et al., 2012).