PRDM16 and gastric cancer: Target at adipocytes: (Zhang et al., 2019b) found that the exosomal ciRS-133 in the plasma of gastric cancer (GC) patients was up-regulated, and in vivo experiments showed that the ciRS-133 secreted by GC cells could be transferred into the pre-adipocytes by exosomes, thereby promoting the expression of Positive Regulatory Domain containing 16 (PRDM16), a key factor determining the fate of adipocyte differentiation, by inhibiting the biological function of miR-133.