RB1 and nasopharyngeal carcinoma: Meanwhile, phosphorylation and dephosphorylation are the key steps to regulate the activities of tumor suppressor genes p53 and Rb1, with the aberrant phosphorylation of both being strongly associated with cancer development, including NPC, breast cancer, lung cancer, and prostate cancer (Bischoff et al., 1990; Gubern et al., 2016; Sanidas et al., 2019).