Moreover, for IL-10 and granzyme A, the difference of expression was observed between the HighBMI and LowBMI in CRC and Non-CRC EVs respectively (granzyme A: p = 0.005 and p = 0.03, IL-10: p = 0.01 and p = 0.03 respectively) As for IFN-G, T cells incubated with CRC-EVs had a higher release of this cytokine as compared to the non-CRC-EVs (p = 0.01). This evidence concerns the gene GZMA and colorectal carcinoma.