T. gondii profilin is recognized by TLR 11/12, resulting in Myd88-dependent IL-12 production, a dominant mechanism driving IL-12 production in mice following intraperitoneal infection (Yarovinsky et al., 2005; Koblansky et al., 2013) or oral infection (Benson et al., 2009). Here, MYD88 is linked to infection.