Mannose-binding lectin (MBL) has also been shown to be crucial for early Th2 responses in an A. fumigatus mouse model of airway inflammation, such that mice deficient in MBL-A displayed a dampened Th2 cytokine response as well as pro-allergic chemokine expression (Hogaboam et al., 2004). The gene discussed is MBL2; the disease is inflammation.