Based on the responses of the microbial communities to current individualized drug therapies (Geller et al., 2017; Yu et al., 2017; Koh et al., 2020), including the currently prevalent chemotherapies using targeted drugs for VEGF and EGFR, we hypothesized that the flora found at different tumor sites will affect the clinical treatment decisions. This evidence concerns the gene EGFR and neoplasm.