One of the autophagic proteins that have been recently described as drug targetable is Vps34, whose inhibition with genetic or pharmacological approaches decreased tumor growth along with increased mice survival due to infiltration of immune cells (NK, CD8+ and CD4+ T effector cells) within the tumor microenvironment, which could turn cold tumors into hot inflamed tumors to enable immunotherapy treatments. This evidence concerns the gene CD4 and neoplasm.