Despite that, many studies support their functions as tumor promotors influencing in the inflammatory response of immune cells and contributing to immune suppression, tumor growth, angiogenesis, and metastasis, as observed in breast cancer cells, where the secretion of IL1-β drives colonization of the bone microenvironment, establishing a metastatic niche and cell proliferation (61, 62). The gene discussed is IL1B; the disease is neoplasm.