TGFβ activates autophagy in early phases of cancer progression; in later phases inhibits ULK1 promoting EMT. Autophagy attenuates EMT by degradation of SNAIL, TWIST and SLUG and activation of ROS-NFκB-HIF1α pathway.ROS-NFκB-HIF1α pathway stimulates SNAIL, N-cadherin expression and thus EMT.Autophagy increase HMGB1 expression and TGF-β/Smad3 signaling enhancing EMT markers.Beclin-1 signaling inhibits EMT by down- regulation of WNT1, ZEB1, and NF-κB. Accelerates EMT increasing Twist and Vimentin. The gene discussed is HMGB1; the disease is cancer.