For instance, in murine tumor models, the treatment with chemotherapy or radiotherapy induced autophagy, which favored translocation of the mannose-6-phosphate receptor (MPR) from autophagosomes to tumor cells surface, rendering the cells more sensitive to granzyme B from activated CTLs, potentiating CTLs killing and immunotherapy (225, 226). The gene discussed is PGRMC1; the disease is neoplasm.