SPN and B-cell chronic lymphocytic leukemia: Interestingly, very recently Sorigue et al, using three immunophenotype-based diagnostic approaches (Matutes score, D’Arena score and CD43 expression) analyzed 597 patients with a chronic lymphoproliferative disorder (CLPD) and found that patients with concurring CLL-like or non-CLL like results according to the three diagnostic strategies were diagnosed with CLL (n = 441) and non-CLL (n =99), respectively (Figure 3) (69, 70).