CDKN1B and neoplasm: Moreover, the increased protein levels of p-Raf-1, p-MEK1/2, p-ERK1/2, and cyclin A1 and the decreased protein level of p27 were also observed in six SiHa-HK2 or HeLa-HK2 cells derived xenografted tumor tissues, compared to their control groups (SiHa-GFP and HeLa-GFP, Figures 6G, H, p<0.05).