To investigate whether HK2 is involved in the development and progression of human cervical carcinoma, immunohistochemistry (IHC) was used to detect HK2 expression in the normal human cervix (NC), high-grade squamous intraepithelial lesions (HSILs), and squamous cervical cancer (SCC) tissues. The gene discussed is HK2; the disease is squamous cell intraepithelial neoplasia.