Verified whether the role of COL10A1 in malignant progression of LUAD is dependent on the FAK pathway by functional rescue assays, as expected, COL10A1 promoted the metastasis of lung adenocarcinoma cells, and this promotion was rescued by inhibiting the expression of FAK (Figures 4E–G), suggesting that the function of COL10A1 was dependent on the FAK pathway. This evidence concerns the gene PTK2 and lung adenocarcinoma.