We have published early work supporting the notion that ovarian cancer TNTs contribute to hypoxia-induced angiogenesis by activating endothelial cells in the TME (63), and also reported that expression of hypoxia inducible factor-1α (HIF-1α) was 2-fold higher in platinum-resistant ovarian cancer cells than platinum-sensitive cells when cultured in hypoxic conditions (8). Here, HIF1A is linked to ovarian carcinoma.