To solve this problem, many researchers have developed numerous methods to classify tumor masses, such as histopathological classification based on the morphological characteristics or immunohistochemical (IHC) markers such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) (Elston, 1999; Perou et al., 2000; Sørlie et al., 2001; Hu et al., 2006; Hofree et al., 2013; Ali et al., 2014; List et al., 2014). This evidence concerns the gene ESR1 and neoplasm.