In the past decade, various mathematical methods using combination of omics biomarkers (Halabi et al., 2003; Gaudreau et al., 2016), including non-coding RNAs, PCA3, TMPRSS2:ERG (Nilsson et al., 2009) were developed to improve PCa diagnosis (Wang et al., 2017; Guo et al., 2018), define the grade (Arvaniti et al., 2018), define the risk (Paulo et al., 2018) and predict survival time (Zupan et al., 2000). The gene discussed is TMPRSS2; the disease is posterior cortical atrophy.