These observations have been reinforced by single-cell RNA-sequencing of stromal and endothelial cells of mice transplanted with acute myeloid leukemia (AML), which revealed a block in adipogenic and osteogenic differentiation programs in MSPCs and osteolineage cells, as well as a reduction of Cxcl12 and Kitl in MSPCs and arteriolar ECs (36). This evidence concerns the gene CXCL12 and acute myeloid leukemia.