More recently, our group demonstrated that pre-malignant preB cells with unrepaired double-stranded DNA breaks induce the downregulation of Il7 transcription in bone marrow MSPCs, while BCR-ABL preB ALL cells downregulate both Il7 and Cxcl12 in MSPCs via undefined mechanisms (21). This evidence concerns the gene CXCL12 and acute lymphoblastic leukemia.