• CRP levels can predict mortality (73), treatment outcome and tumor recurrence in solid tumor renal cell carcinoma and digestive tumors [Shotriya et al. (15)]• Preoperative values are predictive of survival and end stage disease requiring hemodialysis (74)• Elevated preoperative levels correlate with aggressive tumor biology (76)• Elevated CRP/Alb ratio correlate with poor survival after or partial nephrectomy (78). The gene discussed is CRP; the disease is neoplasm.