CRP and neoplasm: Further, given the observations that systemic levels of both IL-6 and IL-1β are elevated in multiple advanced cancers (186, 187), it is conceivable that the evolving tumor and its microenvironment may contribute to an exacerbation of CRP de novo synthesis and continuous secretion, potentially in excess of a slowing rate of conversion to mCRP that results in a demonstrable (and quantifiably significant) increase in systemic pCRP levels (Figure 5).