• Higher conventional levels correlate with tumor size and staging (2)• Higher levels (before or after surgery) are indicators of poor prognosis (1)• Smoking and hsCRP levels did not correlate with increased risk for lung adenocarcinoma (9)• Smoking and lung function with hsCRP can predict bronchial dysplasia than can progress to cancer (14)• Conventional CRP above 40 μg/ml is predictive of metastasis (17)• CRP levels do correlate with level of inflammation which is more pronounced in cancer than COPD (18). The gene discussed is CRP; the disease is neoplasm.