In addition to the identification of PD-L1+ TAMs (123), PD-L1 has been found highly expressed in MDSCs, a population of tumor-infiltrating myeloid cells implicated in inhibition of other cells of the immune system (124, 125), and a MDSC molecular program linked to NF-κB activation has been related to PD-L1 expression (126). Here, CD274 is linked to neoplasm.