Membranous nephropathy (MN) is a rare autoimmune disease (incidence 1.3 cases per 100 000 inhabitants affecting more men than women) (2) with an increasing prevalence (3), characterized by subepithelial immune deposits containing IgG and complement fractions with alteration of the glomerular basement membrane structure (4, 5) related to autoantibodies against podocyte proteins: M-type phospholipase A2 receptor 1 (PLA2R1) or thrombospondin type-1 domain-containing 7A (THSD7A) in 70% and 3% of patients, respectively (6–9). This evidence concerns the gene THSD7A and autoimmune disease.