CASP1 and infection: Under the infection of Salmonella, NLRC4 and NLRP3 inflammasomes could be activated within 1 h, cut the pro-caspase-1 into active caspase-1 in macrophages and induce pyroptosis (Monack et al., 2000; Lara-Tejero et al., 2006; Zhao et al., 2011; Qu et al., 2016).