To verify which signal could regulate the expression of TFEB and lysosomal proteins, BMDMs were pre-treated with caspase-1 inhibitor, ERKi, rapamycin, S31-201 or IKK16 upon the infection of Salmonella. Because LAMP1 is a key marker of lysosome and ATP6V0D2 has a great role in the autophagy-lysosome degradation process (Xia et al., 2019), we tested the protein and gene level of the two and TFEB. The gene discussed is CASP1; the disease is infection.