CYP7A1 and metabolic dysfunction-associated steatohepatitis: Table 2 lists the top 10 most statistically significant DEGS in NASH, ordered by the magnitude of altered expression. The 10 DEGs included two up-regulated genes (CYP7A1, and PEG10), and eight down-regulated genes (FOSB, FOS, IL6, GADD45G, MYC, SLITRK3, JUNB, IGFBP2). Box plots of mRNA expression levels of the 10 DEGs are shown in Figure 2B.