IGFBP2 and metabolic dysfunction-associated steatohepatitis: Of the top-ranked 10 genes, two genes (CYP7A1 and PEG10) were significantly up-regulated in both steatosis and NASH patients, while eight genes (FOSB, FOS, IL6, GADD45G, MYC, SLITRK3, JUNB, and IGFBP2) were significantly down-regulated.