CX3CL1 and obesity due to melanocortin 4 receptor deficiency: The CX3CL1 is one of the first chemokines to be expressed during early hypothalamic inflammation (164), has been shown to be a marker for developing metabolic syndrome (166), its presence associated with increased propensity to develop obesity and increased recruitment of white blood cells into adipose tissue (167), and found to be highly expressed in the hypothalamus in HFD-induced obesity in mice (164).