CAMK2G and HIV-associated neurocognitive disorder: Our data provide strong evidence to support the notion that manipulation of signal transduction pathways to favor cAMP/PKA/pCREBSer133 and to abolish [Ca+2]i/CaMKII/pCREBSer142 is a promising strategy for restoring astrocyte EAAT-2 function in the context of METH abuse and HAND.