SIRT1 and schizophrenia: Although two early studies explore the relationship between SIRT1 gene and susceptibility to schizophrenia, and both suggested that altered expression, mutations, and (or) polymorphisms of SIRT1 might be involved in the pathogenesis of schizophrenia (42), no study to date has explored the relationship between SIRT1 gene and metabolic dysregulation in schizophrenia patients.