In all patients with schizophrenia, our results showed that plasma levels of SIRT1 were negatively correlated with IL-6 (r = −0.345, P = 0.011), IL-10 (r = −0.276, P = 0.043), and TNF-α (r = −0.393, P = 0.003). Here, SIRT1 is linked to schizophrenia.