The TLR4 inhibitors, eritoran, polyamidoamine, and tak-242, have been shown to decrease the inflammatory response in sepsis animals (Fenhammar et al., 2011; Kalil et al., 2011; Teo et al., 2012), and the NLRP3 inhibitor, MCC950, has been shown to have a positive effect in sepsis mice (Kang et al., 2016; Lin et al., 2019). The gene discussed is TLR4; the disease is Sepsis.