It is important to note that mtDNA cannot only be sensed by NLRP3, but also by multi-signaling pathways, such as TLR9 and cyclic GMP-AMP synthase, to induce the progression of sepsis (Schafer et al., 2016; West and Shadel, 2017; Hu et al., 2019). This evidence concerns the gene NLRP3 and Sepsis.