Inhibitors of ADK such as 4-(N-phenylamino)-5-phenyl-7-(5-deoxyribofuranosyl)pyrrolo[2,3-day]pyrimidine (GP683) and ABT-702 were primarily developed for chronic treatment paradigms such as for neuropathic pain and epilepsy and were abandoned due to toxicity in long-term usage (Boison, 2013). This evidence concerns the gene ADK and epilepsy.