The Y402H polymorphism (in CCP7) alters the binding of FH to heparan sulfate (in the BrM) (Parente et al., 2017; Clark and Bishop, 2018) and C reactive protein (CRP, which is present both in the BrM and choroid) (Sjoberg et al., 2007), thus leading to inappropriate complement activation and complement-driven inflammation, with pathological progression to AMD (Clark and Bishop, 2018). The gene discussed is CRP; the disease is age-related macular degeneration.