FH and age-related macular degeneration: This mechanism could be relevant in the presence of the AMD-associated 402H variant of FH, which has been demonstrated to have a more restricted specificity for sulfated GAGs compared to 402Y (Clark et al., 2006; Prosser et al., 2007), and likely has decreased ability to control complement activation at ECM sites, such as the BrM (Clark et al., 2010; Clark and Bishop, 2018).