HMGA2 and Familial prostate cancer: Similar H19 regulatory mechanisms have previously been reported such as the finding that the H19/miR-675 pathway inhibited cell growth and Igf1r expression (Keniry et al., 2012); H19/Let-7-mediated inhibition on the target HMGA2-mediated epithelial to mesenchymal transition (Ma et al., 2014); and the H19/miR-675 axis inhibits prostate cancer metastasis via affecting TGF-β1 expression (Zhu et al., 2014).