PKM and nasopharyngeal carcinoma: For example, phosphorylation of histone H3 at Ser10 was required for AP-1 activation in nasopharyngeal carcinoma (Li et al., 2013); phosphorylation H3 Thr45 by Akt has been reported to facilitate transcriptional termination in response to DNA damage (Hurd et al., 2009); histone H3-Thr11 phosphorylation induced by PKM2 is required for cyclin D1 and c-Myc expression under EGF stimulation (Yang et al., 2012a).