Given that the process of H3 phosphorylation usually recruits a histone modifying enzyme that would in turn generate the second modification (Cheung et al., 2000; Yang et al., 2012a), we supposed histone H3 acetylation may be also involved in EGF-induced PD-L1 expression in HCC cells. The gene discussed is CD274; the disease is hepatocellular carcinoma.