In 2010 the results of the COG ANBL0032 trial were published demonstrating that the 2-years EFS and OS of patients with HR-NB achieving major responses (after standard induction and consolidation -including ASCT-) and receiving anti-GD2 immunotherapy (dinutuximab and cytokines: GM-CSF and IL-2) in addition to isotretinoin were significantly higher (2-y EFS 66 ± 5% and OS 86 ± 4%) compared to those patients receiving isotretinoin alone (2-y EFS 46 ± 5% and OS 75 ± 5%) (Yu et al., 2010). The gene discussed is CSF2; the disease is neuroblastoma.