Additionally, VEGF expression was markedly down-regulated in the LTF and CaD groups compared with that in the DM group (LTF: 0.38 ± 0.05 vs. 0.51 ± 0.07, p < 0.05; CaD: 0.41 ± 0.11 vs. 0.51 ± 0.07, p < 0.05, respectively). The gene discussed is VEGFA; the disease is diabetes mellitus.