Retinal expression of Ang-1 and Tie-2 was markedly down-regulated in the DM group compared with that in the NC group (Ang-1: 0.16 ± 0.07 vs. 0.37 ± 0.12, p < 0.05; Tie-2: 0.23 ± 0.07 vs. 0.77 ± 0.34, p < 0.05, respectively). The gene discussed is ANGPT1; the disease is diabetes mellitus.