TARDBP and amyotrophic lateral sclerosis: The finding that also WM is significantly affected is in line with recent histopathologic studies that hypothesize a cortico-efferent pathway of disease spreading, given the progressive distribution of phosphorylated 43-kDA TAR DNA-binding protein (pTDP-43) in different brain regions in both FTSD patients (Brettschneider et al., 2014) and ALS patients (Braak et al., 2013).