Sox2 appears to be more related to anophthalmia/microphthalmia and hypogonadotropic hypogonadism, while Sox3 tends to be associated to abnormalities of the brain midline and hypopituitarism (reviewed in Kelberman et al., 2009; Webb and Dattani, 2010). This evidence concerns the gene SOX3 and hypopituitarism.