SLC30A3 and Alzheimer disease: Of note, the ZnT3 KO mouse model has been proposed to phenocopy AD pathogenesis as the mice develop age-dependent cognitive deficits that overlap with the ones found in AD, thereby supporting the idea that the synaptic deficiency of the cation may participate in shaping disease progression (Deshpande et al., 2009; Adlard et al., 2010).