CHRNA7 and nervous system disorder: Homomeric α7 nAChRs and heteromeric α4β2∗ nAChRs are predominantly expressed in the human brain (Millar and Harkness, 2008; Colombo et al., 2013) where they contribute to the pathogenesis of a range of neurological disorders including Alzheimer’s disease, schizophrenia, Parkinson’s disease and depression (Freedman et al., 1995; Wang et al., 2000; D’Andrea and Nagele, 2006).